The FDA Modernization Act is the latest addendum to a comprehensive set of consumer health-related laws that have been in place for over a century, beginning with the Pure Food and Drug Act of 1906. This landmark piece of legislation was designed to protect consumers from mislabeled or dangerous food and medicine, at a time when there was little to no regulation in either industry.
Articular cartilage is the elastic tissue that covers the end of a bone at its joint; it provides cushioning and allows for frictionless motion between bones. Unfortunately, articular cartilage is prone to damage, either through injury or age- and usage-based degeneration. This damage progresses over time, eventually leading to osteoarthritis of the joint.
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) possess outstanding potential for use in cardiotoxicity assays as part of pre-clinical drug discovery. Specifically, these cardiomyocytes can be utilized to detect drug-induced proarrhythmia, thereby enabling scientists and medical professionals to evaluate the risk of heart rhythm disturbances from various drugs under development. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative was created by the FDA and the drug discovery field to build on this finding.
Young, healthy cells at early passage, or older, uncultured osteoarthritic cells – your choice. We offer the means for a deeper understanding of authentic chondrocyte behavior.
Broaden your knowledge by comparing healthy and diseased chondrocytes, or expand chondrocyte cultures while maintaining potency and natural phenotype with reduced dedifferentiation.
When you grow CELLvo™ Human Chondrocyte cells on CELLvo™ Matrix, you have the ability to truly empower your research.
StemBioSys Scientist, Anne Sheldrake, was invited to speak at Texas Public Radio’s first “Worth Repeating” event of their 5th season. She shared her story of confronting a mental health issue while pursuing a PhD. It is important to share these stories in the biosciences industry as graduate student mental health is too often ignored. Anne confronted and overcame an eating disorder, and for the last 2 years has been a key driver of innovation and new product development at StemBioSys. Anne, thank you for sharing your story.
CELLvo™ Matrix has recently been shown to improve the isolation and expansion of human chondrocytes, while minimizing significant change in phenotype [1]. Here, we compare gene expression of CELLvo™ Human Articular Chondrocytes (HC-A) to other commercially available articular chondrocyte products. Additionally, we examine the effect of culture on substrate choice (CELLvo™ Chondrocyte-Derived (CD) Matrix (in development) vs. tissue culture plastic (TCP)) on chondrocyte gene expression. We show that CELLvo™ HC-A are the only chondrocytes with a native phenotype, and that CELLvo™ CD Matrix minimizes loss of phenotype during in vitro expansion.
